The recent discussion on the application of nuclear technologies in space, particularly regarding the development of nuclear power systems and engines for spacecraft, highlights a pivotal shift in energy generation methods for extraterrestrial missions. Currently, 99% of spacecraft rely on solar panels and batteries, which are inadequate for long-duration voyages beyond Earth’s orbit due to diminishing sunlight and energy output. Nuclear propulsion could reduce the travel time to Mars to as little as two months, though significant technical and financial challenges remain. While nuclear thermal rocket engines have only been tested on the ground, the U.S. aims to prototype a space nuclear engine for orbital missions, with potential plans for lunar transportation. The interest in nuclear energy for space exploration extends globally, with patents reflecting rising involvement from various nations including the U.S., Russia, China, and several European countries. The pressing need for reliable energy sources on the Moon and Mars underscores the necessity of compact nuclear reactors, especially given the extreme environmental conditions, including prolonged darkness on the Moon. This strategic pivot towards nuclear energy could enable sustainable human presence on these celestial bodies, thereby advancing human exploration in the solar system and fostering international collaboration in space innovations.